Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316001 | 1.00 | HTT (0.40) | HTTPOLBALDH1A1TDP1KMT2A | |
| Hydrochloric Acid SCHEMBL10584749 | 0.81 | POLB (0.42) | HTTPOLBALDH1A1TDP1KMT2A | |
| SCHEMBL26120999 | 0.75 | KMT2A (0.44) | HTTALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL7301588 | 0.74 | HTT (0.53) | HTTPOLBALDH1A1TDP1KMT2A | |
| SCHEMBL8029112 | 0.74 | HTT (0.53) | HTTPOLBALDH1A1TDP1KMT2A | |
| SCHEMBL11221919 | 0.73 | PRSS1 (0.36) | POLBKMT2A | |
| SCHEMBL7311353 | 0.73 | HTT (0.58) | HTTALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL9673196 | 0.73 | HTT (0.58) | HTTALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL7442911 | 0.73 | HTT (0.58) | HTTALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL9673207 | 0.73 | HTT (0.58) | HTTALDH1A1TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818443-B1 | Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases | AMERICAN CYANAMID CO (US) | 2001-12-05 | — | — | EP | disclosed |
| US-6160132-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| US-6124502-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 2000-09-26 | — | — | US | disclosed |
| US-5852213-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0818443-A2 | Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases | American Cyanamid Company (US) | 1998-01-14 | — | — | EP | disclosed |