Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.59 |
| ▸ | PDE1A | P54750 | 5/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.59 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310252 | 0.84 | PDE5A (0.50) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL6197039 | 0.82 | KMT2A (0.53) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL7304817 | 0.81 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL5875796 | 0.76 | MEN1 (0.60) | — | |
| SCHEMBL6198473 | 0.75 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE4B | |
| SCHEMBL12047459 | 0.71 | CA12 (0.77) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL6201352 | 0.71 | KMT2A (0.51) | PDE5APDE1APDE1BPDE1CCA12 | |
| SCHEMBL5827157 | 0.71 | CYP2C9 (0.65) | CA12CA9 | |
| SCHEMBL5875625 | 0.71 | TSHR (0.57) | PDE5ACA12CA9 | |
| SCHEMBL4551788 | 0.70 | POLB (0.60) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |