Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197039 | 0.86 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL7310252 | 0.85 | PDE5A (0.50) | KMT2AMEN1PDE5APDE1APDE1B | |
| SCHEMBL6194105 | 0.85 | KMT2A (0.45) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL6197854 | 0.82 | KMT2A (0.55) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL6194610 | 0.81 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL6197110 | 0.80 | KMT2A (0.54) | KMT2APOLBPDE5ALMNARAB9A | |
| SCHEMBL6332500 | 0.79 | KMT2A (0.52) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL6197356 | 0.78 | SGMS2 (0.42) | KMT2AMEN1LMNARXFP1 | |
| SCHEMBL7002737 | 0.76 | KMT2A (0.53) | KMT2AMEN1POLBPDE5ALMNA | |
| SCHEMBL4565717 | 0.74 | TERT (0.56) | KMT2AMEN1POLBPDE5APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |