Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 3/20 | 0.44 |
| ▸ | PPIB | P23284 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | PPIG | Q13427 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16063626 | 0.86 | HTT (0.48) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL15832142 | 0.85 | PPID (0.60) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL11864885 | 0.83 | PPID (0.40) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL20558220 | 0.82 | CYP4F2 (0.48) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL9752201 | 0.81 | CYP4F2 (0.49) | NLRP3ALDH1A1HSD17B10CHEK1KMT2A | |
| SCHEMBL10682599 | 0.79 | PPID (0.48) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL4003642 | 0.79 | HTT (0.55) | PPIDNLRP3ALDH1A1KMT2AMAPT | |
| SCHEMBL14159900 | 0.78 | PPID (0.42) | PPIDPPIBPPIAPPIGALDH1A1 | |
| SCHEMBL30505642 | 0.78 | PPID (0.42) | PPIDPPIBPPIAPPIGNLRP3 | |
| SCHEMBL278947 | 0.78 | PPID (0.42) | PPIDPPIBPPIAPPIGNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4208521-A | Process for the preparation of imidazo[2,1-b]quinazolinones | BRISTOL-MYERS COMPANY (US) | 1980-06-17 | — | — | US | claimed |
| US-RE31617-E | ANTICOAGULANTS; HYPOTENSIVE AND BRONCHODILATOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| US-4208521-A | Process for the preparation of imidazo[2,1-b]quinazolinones | BRISTOL-MYERS COMPANY (US) | 1980-06-17 | — | — | US | disclosed |
| US-3983120-A | HYPOTENSIVES, ANTICLOTTING | BRISTOL-MYERS COMPANY (US) | 1976-09-28 | — | — | US | disclosed |
| US-3983119-A | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones | BRISTOL-MYERS COMPANY (US) | 1976-09-28 | — | — | US | disclosed |
| US-3932407-A | BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTICOAGULANTS | BRISTOL-MYERS COMPANY (US) | 1976-01-13 | — | — | US | disclosed |