Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320567 | 0.92 | PDE4B (0.48) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4051034 | 0.86 | PDE4B (0.39) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4058822 | 0.83 | PDE4B (0.36) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7308904 | 0.82 | PDE4B (0.56) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7367744 | 0.79 | PDE4B (0.45) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7308311 | 0.78 | PDE4B (0.66) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7314230 | 0.74 | PDE4B (0.52) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7307576 | 0.73 | PDE4B (0.48) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL3031978 | 0.71 | PDE4B (0.57) | PDE4BADORA1 | |
| SCHEMBL7309937 | 0.71 | PDE4B (0.58) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |