Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051034 | 0.86 | PDE4B (0.39) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7320567 | 0.83 | PDE4B (0.48) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7367748 | 0.81 | PDE4B (0.47) | PDE4BTP53FABP3FABP4FABP5 | |
| SCHEMBL7308254 | 0.79 | PDE4B (0.54) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4058822 | 0.79 | PDE4B (0.36) | PDE4BTP53ADORA1ADORA2AADORA2B | |
| SCHEMBL3031978 | 0.73 | PDE4B (0.57) | PDE4BTP53ADORA1 | |
| SCHEMBL3022288 | 0.68 | PDE4B (0.47) | PDE4BTP53ADORA1ADORA2AADORA2B | |
| SCHEMBL3022169 | 0.68 | PDE4B (0.47) | PDE4BTP53 | |
| SCHEMBL3029571 | 0.67 | PDE4B (0.49) | PDE4BTP53 | |
| SCHEMBL4052027 | 0.67 | PDE4B (0.54) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |