Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.79 |
| ▸ | DRD2 | P14416 | 8/20 | 0.79 |
| ▸ | HRH2 | P25021 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14713910 | 0.92 | DRD2 (0.90) | DRD3DRD2 | |
| SCHEMBL10123839 | 0.92 | DRD2 (0.90) | DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7317109 | 0.86 | DRD2 (0.95) | DRD3DRD2DRD4 | |
| SCHEMBL7322498 | 0.83 | DRD3 (0.67) | DRD3DRD2HRH2ADRA2ADRD4 | |
| SCHEMBL6032194 | 0.83 | DRD3 (0.67) | DRD3DRD2HRH2ADRA2ADRD4 | |
| Hydrochloric Acid SCHEMBL7314833 | 0.82 | DRD2 (0.59) | DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL7318892 | 0.81 | DRD3 (0.65) | DRD3DRD2HRH2ADRA2ADRD4 | |
| SCHEMBL15076626 | 0.81 | DRD3 (0.78) | DRD3DRD2HRH2ADRA2ADRD4 | |
| SCHEMBL8198066 | 0.81 | DRD3 (0.78) | DRD3DRD2HRH2ADRA2ADRD4 | |
| SCHEMBL11885228 | 0.81 | DRD3 (0.78) | DRD3DRD2HRH2ADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |