Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987234 | 0.85 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDHTTRECQL | |
| Water SCHEMBL21776630 | 0.84 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL2121837 | 0.81 | HCRTR1 (0.35) | ALDH1A1HPGD | |
| SCHEMBL1969215 | 0.81 | CYP3A4 (0.34) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL7298547 | 0.78 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL2626708 | 0.77 | GLA (0.33) | ALDH1A1GAA | |
| SCHEMBL2121160 | 0.77 | GLA (0.33) | ALDH1A1GAA | |
| SCHEMBL6857533 | 0.75 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDHTTRECQL | |
| SCHEMBL27446651 | 0.75 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL27334875 | 0.75 | GAA (0.33) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0503785-A1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-09-16 | — | — | EP | disclosed |