Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315521 | 0.94 | PDE4B (0.68) | PDE4BADORA1ADORA2BADORA2AALDH1A1 | |
| SCHEMBL8443541 | 0.86 | PDE4B (0.59) | PDE4BADORA1ADORA2BADORA2AALDH1A1 | |
| SCHEMBL2820999 | 0.81 | PDE4B (0.89) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2824900 | 0.81 | PDE4B (0.91) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7315507 | 0.81 | PDE4B (0.64) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7319231 | 0.81 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2AMAPT | |
| SCHEMBL7315712 | 0.80 | PDE4B (0.60) | PDE4BADORA1ADORA2BADORA2AMAPT | |
| SCHEMBL12027297 | 0.79 | PDE4B (0.51) | PDE4BADORA1ADORA2BADORA2AALDH1A1 | |
| SCHEMBL8442360 | 0.78 | PDE4B (0.60) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2826196 | 0.76 | PDE4B (0.85) | PDE4BADORA1ADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |