Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317541 | 0.95 | PDE4B (0.63) | PDE4BADORA1ADORA2BADORA2ALMNA | |
| SCHEMBL7311271 | 0.94 | PDE4B (0.64) | PDE4BADORA1ADORA2BADORA2ALMNA | |
| SCHEMBL7315642 | 0.89 | PDE4B (0.56) | PDE4BADORA1ADORA2BADORA2AAVPR1B | |
| SCHEMBL7305549 | 0.88 | PDE4B (0.63) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7307160 | 0.87 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7316189 | 0.85 | PDE4B (0.57) | PDE4BADORA1ADORA2BADORA2ALMNA | |
| SCHEMBL7315507 | 0.84 | PDE4B (0.64) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7315729 | 0.84 | PDE4B (0.49) | PDE4BADORA1ADORA2BADORA2AHTT | |
| SCHEMBL7309072 | 0.83 | PDE4B (0.64) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL7312351 | 0.82 | PDE4B (0.58) | PDE4BADORA1ADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |