Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 13/20 | 0.67 |
| ▸ | AVPR2 | P30518 | 10/20 | 0.67 |
| ▸ | OXTR | P30559 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624184 | 0.88 | AVPR1A (0.51) | AVPR1AAVPR2HPGD | |
| SCHEMBL7329926 | 0.88 | AVPR1A (0.52) | AVPR1AAVPR2 | |
| SCHEMBL6622410 | 0.85 | AVPR1A (0.52) | AVPR1AAVPR2OXTR | |
| SCHEMBL8314472 | 0.84 | AVPR2 (0.51) | AVPR1AAVPR2 | |
| SCHEMBL6625490 | 0.84 | AVPR1A (0.48) | AVPR1AAVPR2OXTR | |
| SCHEMBL7335590 | 0.84 | AVPR1A (0.52) | AVPR1AAVPR2ALDH1A1HPGD | |
| SCHEMBL5738340 | 0.83 | AVPR2 (0.62) | AVPR1AAVPR2OXTR | |
| SCHEMBL7386820 | 0.81 | RAB9A (0.54) | AVPR1AAVPR2ALDH1A1HPGD | |
| SCHEMBL6624713 | 0.80 | AVPR1A (0.44) | AVPR1AAVPR2ALDH1A1 | |
| SCHEMBL6624718 | 0.80 | AVPR1A (0.44) | AVPR1AAVPR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805813-B1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID CO (US) | 2002-05-15 | — | — | EP | claimed |
| WO-1996022292-A1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | claimed |
| US-5521173-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-28 | — | — | US | claimed |
| EP-0805813-B1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID CO (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-1996022292-A1 | TRICYCLIC VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5521173-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |