Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.53 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.53 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9426254 | 0.99 | METAP1 (0.54) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 | |
| SCHEMBL7345441 | 0.83 | CYP24A1 (0.53) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 | |
| SCHEMBL7303893 | 0.82 | CYP19A1 (0.49) | METAP1CYP19A1ACHE | |
| SCHEMBL8012038 | 0.81 | METAP1 (0.78) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 | |
| SCHEMBL7590283 | 0.81 | METAP1 (0.78) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 | |
| Hydrochloric Acid SCHEMBL9425569 | 0.81 | CYP19A1 (0.48) | METAP1CYP19A1ACHE | |
| Hydrochloric Acid SCHEMBL10341505 | 0.80 | METAP1 (0.78) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 | |
| SCHEMBL7303491 | 0.78 | CYP19A1 (0.50) | METAP1CYP19A1ACHE | |
| Hydrochloric Acid SCHEMBL9426786 | 0.77 | CYP19A1 (0.49) | METAP1CYP19A1ACHE | |
| SCHEMBL7590969 | 0.77 | METAP1 (0.74) | METAP1CYP24A1CYP27A1CYP26A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581677-B1 | Cycloalkylalkylamines which are sigma-receptor ligands, process for preparing them and their application in therapy | JOUVEINAL INST RECH (FR) | 1997-01-08 | — | — | EP | disclosed |
| EP-0581677-A1 | Cycloalkylalkylamines which are sigma-receptor ligands, process for preparing them and their application in therapy | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1994-02-02 | — | — | EP | disclosed |