Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.64 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312351 | 0.96 | PDE4B (0.58) | PDE4BADORA1ADORA2AADORA2BPIK3CD | |
| SCHEMBL7305549 | 0.93 | PDE4B (0.63) | PDE4BADORA1ADORA2AADORA2BMAP4K4 | |
| SCHEMBL7307160 | 0.89 | PDE4B (0.57) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7315729 | 0.88 | PDE4B (0.49) | PDE4BADORA1ADORA2AADORA2BCYP2C9 | |
| SCHEMBL7319363 | 0.85 | PDE4B (0.61) | PDE4BADORA1ADORA2AADORA2BCAMK2D | |
| SCHEMBL7307669 | 0.84 | PDE4B (0.64) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7314819 | 0.84 | PDE4B (0.64) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7306242 | 0.84 | PDE4B (0.72) | PDE4BADORA1ADORA2AADORA2BMAP4K4 | |
| SCHEMBL7310969 | 0.84 | PDE4B (0.49) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL7312390 | 0.84 | PDE4B (0.52) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |