Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315642 | 0.93 | PDE4B (0.56) | PDE4BADORA2AADORA1ADORA2BCYP3A4 | |
| SCHEMBL7312351 | 0.89 | PDE4B (0.58) | PDE4BADORA2AADORA1ADORA2B | |
| SCHEMBL7309072 | 0.88 | PDE4B (0.64) | PDE4BADORA2AADORA1ADORA2BCYP2C9 | |
| SCHEMBL7317541 | 0.87 | PDE4B (0.63) | PDE4BADORA2AADORA1ADORA2BCYP2D6 | |
| SCHEMBL7311271 | 0.86 | PDE4B (0.64) | PDE4BADORA2AADORA1ADORA2BCYP2D6 | |
| SCHEMBL7303361 | 0.84 | PDE4B (0.49) | PDE4BADORA2AADORA1ADORA2B | |
| SCHEMBL7319231 | 0.84 | PDE4B (0.57) | PDE4BADORA2AADORA1ADORA2BHTT | |
| SCHEMBL7315323 | 0.83 | PDE4B (0.47) | PDE4BADORA2AADORA1ADORA2B | |
| SCHEMBL7314416 | 0.83 | PDE4B (0.43) | PDE4BADORA2AADORA1ADORA2BHTT | |
| SCHEMBL7307160 | 0.82 | PDE4B (0.57) | PDE4BADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |