Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12231980 | 0.88 | PARP1 (1.00) | PARP1 | |
| SCHEMBL7302722 | 0.88 | PARP1 (0.79) | PARP1 | |
| SCHEMBL7300722 | 0.88 | PARP1 (0.79) | PARP1HTR7 | |
| SCHEMBL7307887 | 0.88 | PARP1 (0.79) | PARP1HTR1AHTR7HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7301292 | 0.87 | PARP1 (0.98) | PARP1 | |
| SCHEMBL7302586 | 0.85 | PARP1 (0.75) | PARP1MAPTKDM4EHTR1AHTR7 | |
| SCHEMBL7299268 | 0.85 | PARP1 (0.73) | PARP1 | |
| SCHEMBL7305161 | 0.84 | PARP1 (0.73) | PARP1 | |
| SCHEMBL7308879 | 0.82 | PARP1 (0.70) | PARP1 | |
| Sulfuric Acid SCHEMBL7308620 | 0.82 | PARP1 (0.71) | PARP1MEN1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |