Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | FPR2 | P25090 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304298 | 0.85 | MEN1 (0.46) | CYP2C9CYP2C19FPR2MEN1KMT2A | |
| SCHEMBL20335126 | 0.79 | FPR2 (0.73) | CYP2C9CYP2C19FPR2MEN1KMT2A | |
| SCHEMBL10795899 | 0.79 | FPR2 (0.73) | CYP2C9CYP2C19FPR2MEN1KMT2A | |
| SCHEMBL11569906 | 0.73 | MME (0.56) | MEN1KMT2AATMMAPK1LMNA | |
| SCHEMBL9390024 | 0.72 | HSD17B10 (0.54) | CYP2C9CYP2C19FPR2MEN1KMT2A | |
| SCHEMBL9056827 | 0.72 | HSD17B10 (0.66) | MEN1KMT2AMAPK1HSD17B10LMNA | |
| SCHEMBL6374964 | 0.72 | HSD17B10 (0.66) | MEN1KMT2AMAPK1HSD17B10LMNA | |
| SCHEMBL15971313 | 0.72 | HSD17B10 (0.66) | MEN1KMT2AMAPK1HSD17B10LMNA | |
| SCHEMBL14467852 | 0.72 | HSD17B10 (0.57) | MEN1KMT2AMAPK1HSD17B10EPHX2 | |
| Benzene SCHEMBL11580862 | 0.71 | HSD17B10 (0.70) | MEN1KMT2AHSD17B10GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494071-B1 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-04-16 | — | — | EP | disclosed |
| US-5430025-A | Elastase-inhibiting peptides bearing a C-terminal trifluoromethylketone moiety | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5296591-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0494071-A2 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |