Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 13/20 | 0.64 |
| ▸ | MAOB | P27338 | 13/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306995 | 0.92 | MAOB (0.64) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7309846 | 0.85 | MAOA (0.69) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7306011 | 0.83 | PDE3B (0.65) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7317785 | 0.79 | P2RX4 (0.41) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7307973 | 0.79 | PDE3B (0.94) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7315341 | 0.78 | PDE3B (0.71) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7313271 | 0.78 | MAOB (0.52) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL7310807 | 0.78 | MAOB (0.69) | MAOAMAOBPDE3BPDE3AMEN1 | |
| SCHEMBL24116871 | 0.77 | PDE3B (0.65) | MAOAMAOBPDE3BPDE3AMEN1 | |
| Cilostazol SCHEMBL16128 | 0.76 | PDE3B (1.00) | MAOAMAOBPDE3BPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277479-A | ANTI-ASTHMATIC, HYPOTENSIVE, ANTI-ULCER, ANTIINFLAMMATORY, VASODILATION, ENZYME INHIBITORS, ANTICOAGULANTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-07-07 | — | — | US | disclosed |