Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307408 | 0.95 | PPARG (0.36) | AGTR1AGTR2PPARG | |
| SCHEMBL7310628 | 0.92 | AGTR1 (0.36) | AGTR1AGTR2EDNRATSHRPDE2A | |
| SCHEMBL7305287 | 0.87 | BRS3 (0.36) | AGTR1AGTR2PPARG | |
| SCHEMBL3841057 | 0.80 | AGTR1 (0.41) | AGTR1AGTR2PPARG | |
| SCHEMBL7308925 | 0.75 | AGTR1 (0.39) | AGTR1AGTR2PPARG | |
| SCHEMBL9251216 | 0.74 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL3841156 | 0.74 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL7310230 | 0.72 | AGTR1 (0.49) | AGTR1AGTR2PPARG | |
| SCHEMBL4609709 | 0.72 | LTB4R2 (0.60) | CNR2CNR1 | |
| SCHEMBL1673090 | 0.72 | AGTR1 (0.43) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545912-B1 | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0545912-A2 | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1993-06-09 | — | — | EP | disclosed |
| EP-0503785-A1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1992-09-16 | — | — | EP | disclosed |