Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317484 | 0.90 | HDAC6 (0.44) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7321589 | 0.80 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7325419 | 0.80 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7322983 | 0.79 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7314089 | 0.78 | HDAC6 (0.46) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7310319 | 0.78 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7317784 | 0.78 | HDAC6 (0.44) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7325410 | 0.74 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| SCHEMBL7317107 | 0.73 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC10HDAC3 | |
| Hydrochloric Acid SCHEMBL7319311 | 0.73 | ADAM17 (0.43) | HDAC6HDAC1HDAC8HDAC10HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901465-B1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO SPA (IT) | 2000-09-27 | — | — | EP | disclosed |
| US-6034096-A | Compounds with anti-inflammatory and immunosuppressive activities | ITALFARMACO S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |