Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.71 |
| ▸ | ITGA2B | P08514 | 16/20 | 0.71 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | C1S | P09871 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ITGAM | P11215 | 1/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884227 | 0.93 | ITGB3 (0.66) | ITGB3ITGA2BST14F2PLG | |
| SCHEMBL9394183 | 0.86 | ITGB3 (0.68) | ITGB3ITGA2BST14F2ITGB2 | |
| SCHEMBL7307289 | 0.85 | ITGB3 (0.70) | ITGB3ITGA2BST14ITGB2ITGAM | |
| SCHEMBL7389300 | 0.83 | ITGB3 (1.00) | ITGB3ITGA2BST14 | |
| SCHEMBL7388492 | 0.82 | ITGB3 (0.82) | ITGB3ITGA2BST14F2PRSS1 | |
| SCHEMBL7390323 | 0.81 | ITGB3 (0.76) | ITGB3ITGA2BST14F2PRSS1 | |
| SCHEMBL7330005 | 0.81 | ITGB3 (0.55) | ITGB3ITGA2BST14F2PLG | |
| SCHEMBL7347492 | 0.80 | ITGB3 (1.00) | ITGB3ITGA2BST14F2PRSS1 | |
| SCHEMBL7306809 | 0.79 | ITGB3 (0.70) | ITGB3ITGA2BPRSS1 | |
| SCHEMBL9394197 | 0.79 | ITGB3 (0.62) | ITGB3ITGA2BST14PRSS1ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | claimed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | claimed |
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |