Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | PPM1B | O75688 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.36 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PPP5C | P53041 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168943 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL1330580 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL16003245 | 0.82 | KDM4E (0.30) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL18789034 | 0.78 | POLB (0.36) | — | |
| SCHEMBL16657577 | 0.76 | — | — | |
| SCHEMBL18588303 | 0.76 | — | — | |
| SCHEMBL2692834 | 0.76 | — | — | |
| SCHEMBL7085873 | 0.71 | CA1 (0.32) | SMN1; SMN2CA1CA2CA4KMT2A | |
| SCHEMBL18427530 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EGMNNPPM1BLMNA | |
| SCHEMBL7282746 | 0.71 | SMN1; SMN2 (0.33) | SMN1; SMN2KDM4EGMNNPPM1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0105919-B1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |
| EP-0093084-B1 | 1-CARBOXYALKANOYLINDOLINE-2-CARBOXYLIC-ACID ESTERS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR THERAPEUTIC USE | CIBA-GEIGY AG (CH) | 1986-03-12 | — | — | EP | disclosed |
| US-4479963-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0105919-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES. | CIBA GEIGY AG (CH) | 1984-04-25 | — | — | EP | disclosed |
| WO-1983003828-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1983-11-10 | — | — | WO | disclosed |
| EP-0093084-A1 | 1-Carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use | CIBA-GEIGY AG (CH) | 1983-11-02 | — | — | EP | disclosed |
| US-4401818-A | HYPOTENSIVE AGENTS, CARDIOACTIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-08-30 | — | — | US | disclosed |
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0050850-A1 | 1-Carboxyalkanoylindolin-2-carboxylic acids and derivatives thereof, processes for their preparation, and pharmaceutical compositions containing these compounds | CIBA-GEIGY AG (CH) | 1982-05-05 | — | — | EP | disclosed |