Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046757 | 0.89 | MAPT (0.53) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10881776 | 0.85 | NPC1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL1640023 | 0.81 | RAB9A (0.73) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL29394052 | 0.81 | RAB9A (0.73) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL25568056 | 0.80 | NPC1 (0.83) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL11616088 | 0.80 | RAB9A (0.61) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL11236972 | 0.80 | MAPT (1.00) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL2995600 | 0.79 | MAPT (0.67) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10878729 | 0.78 | RAB9A (0.65) | KMT2AALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL19321878 | 0.78 | CYP3A4 (0.61) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927035-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0927035-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-07-07 | — | — | EP | disclosed |
| US-5872138-A | INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION IN A MAMMAL | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| WO-1998010763-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-03-19 | — | — | WO | disclosed |