SCHEMBL7311145

SCHEMBL7311145

COc1[c]ccc(OS(C)(=O)=O)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.40
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 2/20 0.36
GAA P10253 1/20 0.36
CA2 P00918 5/20 0.35
CA5A P35218 2/20 0.35
TDP1 Q9NUW8 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
MEN1 O00255 1/20 0.34
PSMD14 O00487 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
ALPL P05186 2/20 0.33
ALPI P09923 1/20 0.33
CA12 O43570 2/20 0.33
CA1 P00915 1/20 0.32
CA9 Q16790 1/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28387862 0.89 ALDH1A1 (0.41) HPGDALDH1A1KDM4EGAACA2
SCHEMBL77754 0.78 CA1 (0.39) ALDH1A1KDM4EGAACA2TDP1
SCHEMBL15067718 0.78 HPGD (0.41) HPGDALDH1A1KDM4EGAACA2
SCHEMBL28113389 0.77 CA1 (0.38) ALDH1A1KDM4ECA2MEN1MAPT
SCHEMBL27330242 0.77 CA1 (0.38) ALDH1A1KDM4ECA2MEN1MAPT
SCHEMBL27431792 0.77 CA1 (0.38) ALDH1A1KDM4ECA2MEN1MAPT
SCHEMBL15066795 0.76 ALDH1A1 (0.40) HPGDALDH1A1KDM4EGAACA2
SCHEMBL4603285 0.76 ALDH1A1 (0.40) HPGDALDH1A1KDM4EGAACA2
SCHEMBL15066595 0.76 ALDH1A1 (0.40) HPGDALDH1A1KDM4EGAACA2
SCHEMBL27267545 0.75 CA1 (0.37) ALDH1A1KDM4ECA2MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0841924-B1 BENZIMIDAZOLE COMPOUNDS UNIV NEWCASTLE VENTURES LTD (GB) 2002-10-02 EP claimed
EP-0841924-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1998-05-20 EP claimed
WO-1997004771-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1997-02-13 WO claimed
EP-0841924-B1 BENZIMIDAZOLE COMPOUNDS UNIV NEWCASTLE VENTURES LTD (GB) 2002-10-02 EP disclosed
US-6310082-B1 PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2001-10-30 US disclosed
US-6100283-A PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 2000-08-08 US disclosed
EP-0841924-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1998-05-20 EP disclosed
WO-1997004771-A1 BENZIMIDAZOLE COMPOUNDS NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) 1997-02-13 WO disclosed