Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986798 | 0.78 | NPC1 (0.62) | SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL8986800 | 0.78 | NPC1 (0.62) | SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL7315180 | 0.78 | ESR1 (0.39) | ESR1KCNH2KDM4ESIGMAR1NPC1 | |
| Hydrochloric Acid SCHEMBL11798523 | 0.77 | NPC1 (0.61) | POLBMAPK1SIGMAR1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11798527 | 0.77 | NPC1 (0.61) | POLBMAPK1SIGMAR1NPC1RAB9A | |
| SCHEMBL7306213 | 0.77 | POLB (0.49) | POLBKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL7317224 | 0.77 | ESR1 (0.35) | ESR1KCNH2DPP4KDM4ESIGMAR1 | |
| SCHEMBL28797485 | 0.75 | APAF1 (0.51) | ESR1KCNH2POLBKDM4EALDH1A1 | |
| SCHEMBL3955675 | 0.74 | TAAR1 (0.53) | ESR1KCNH2SIGMAR1 | |
| SCHEMBL8476243 | 0.74 | TAAR1 (0.53) | ESR1KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE31617-E | ANTICOAGULANTS; HYPOTENSIVE AND BRONCHODILATOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| US-3983120-A | HYPOTENSIVES, ANTICLOTTING | BRISTOL-MYERS COMPANY (US) | 1976-09-28 | — | — | US | disclosed |
| US-3932407-A | BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTICOAGULANTS | BRISTOL-MYERS COMPANY (US) | 1976-01-13 | — | — | US | disclosed |