Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316080 | 0.88 | PDE3B (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7320125 | 0.87 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7310529 | 0.87 | PDE3B (0.35) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7316529 | 0.86 | PDE3B (0.35) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7318132 | 0.86 | NPC1 (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7306426 | 0.84 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10648197 | 0.82 | PDE3B (0.37) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7320121 | 0.82 | PDE3B (0.37) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10652213 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10665307 | 0.81 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761416-A | ENZYME INHIBITORS, INOTROPIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |