Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346516 | 0.90 | AGTR1 (0.44) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9350422 | 0.89 | AGTR1 (0.43) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9346832 | 0.85 | AGTR1 (0.45) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7292232 | 0.85 | AGTR1 (0.44) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9350575 | 0.81 | AGTR1 (0.44) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9350518 | 0.81 | AGTR1 (0.44) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9350551 | 0.81 | AGTR1 (0.44) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9346610 | 0.79 | CYP3A4 (0.40) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL9347440 | 0.79 | AGTR1 (0.42) | AGTR1CYP3A4CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7284290 | 0.79 | AGTR1 (0.42) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516392-B1 | Naphthyridine derivatives as angiotensin II inhibitors | ASTRAZENECA AB (SE) | 2001-08-29 | — | — | EP | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |