Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | ACE | P12821 | 7/20 | 0.43 |
| ▸ | CTSD | P07339 | 4/20 | 0.42 |
| ▸ | CTSE | P14091 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PEPD | P12955 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364608 | 0.89 | ACE (0.51) | RENACEKDM4EF2LMNA | |
| SCHEMBL7313910 | 0.84 | ELANE (0.40) | RENCTSDCTSEELANEBACE1 | |
| SCHEMBL29421107 | 0.83 | ACE (0.45) | RENACEKDM4EF2LMNA | |
| SCHEMBL7313903 | 0.82 | ELANE (0.40) | RENCTSDCTSEF2ELANE | |
| SCHEMBL2195410 | 0.79 | ACE (0.50) | RENACEKDM4EF2LMNA | |
| SCHEMBL7320486 | 0.79 | SMN1; SMN2 (0.48) | RENACEKDM4EF2LMNA | |
| SCHEMBL7320499 | 0.79 | SMN1; SMN2 (0.48) | RENACEKDM4EF2LMNA | |
| SCHEMBL30051863 | 0.78 | ACE (0.49) | RENACEKDM4EF2LMNA | |
| SCHEMBL7314536 | 0.77 | MALT1 (0.51) | RENACECTSDCTSEACE2 | |
| SCHEMBL5208748 | 0.77 | CTSD (0.49) | ACECTSDCTSELTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |