Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.93 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.84 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.71 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246679 | 0.96 | AKR1C3 (1.00) | AKR1C3AKR1C1EIF2AK3MCOLN3TSHR | |
| SCHEMBL22191886 | 0.93 | AKR1C3 (1.00) | AKR1C3AKR1C1EIF2AK3MCOLN3TSHR | |
| SCHEMBL7303194 | 0.91 | AKR1C3 (1.00) | AKR1C3AKR1C1EIF2AK3MCOLN3TSHR | |
| SCHEMBL7304595 | 0.86 | AKR1C3 (0.82) | AKR1C3AKR1C1EIF2AK3MCOLN3TSHR | |
| SCHEMBL25269754 | 0.85 | AKR1C3 (0.80) | AKR1C3AKR1C1EIF2AK3MCOLN3TSHR | |
| SCHEMBL6791588 | 0.83 | AKR1C3 (0.85) | AKR1C3AKR1C1MCOLN3TSHRKMT2A | |
| SCHEMBL5244699 | 0.83 | EIF2AK3 (0.74) | AKR1C3AKR1C1EIF2AK3TSHRMEN1 | |
| SCHEMBL6079186 | 0.82 | AKR1C3 (0.75) | AKR1C3AKR1C1EIF2AK3TSHRMAPT | |
| SCHEMBL4701073 | 0.82 | MAPT (0.77) | AKR1C3AKR1C1TSHRMAPTLMNA | |
| SCHEMBL21669903 | 0.82 | MAPT (0.77) | AKR1C3AKR1C1TSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520336-A2 | Aldehyde derivatives and their use as calpain inhibitors | FUJIREBIO Inc. (JP) | 1992-12-30 | — | — | EP | disclosed |