Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12614695 | 0.93 | KDM5A (0.53) | THRATHRBPARP10TLR4TLR2 | |
| SCHEMBL4568858 | 0.86 | SLC2A1 (0.52) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL29818757 | 0.85 | SIRT2 (0.50) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL2205210 | 0.85 | SIRT2 (0.50) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL7316033 | 0.83 | POLB (0.52) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL4569158 | 0.82 | TLR4 (0.50) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL3961299 | 0.82 | PARP10 (0.61) | THRATHRBPARP10PARP15 | |
| SCHEMBL31220919 | 0.82 | TLR4 (0.50) | SLC2A1SIRT2PARP10TLR4TLR2 | |
| SCHEMBL8899048 | 0.82 | SIRT2 (0.47) | THRATHRBSLC2A1SIRT2PARP10 | |
| SCHEMBL25823269 | 0.82 | SLC2A1 (0.48) | SLC2A1SIRT2PARP10TLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927035-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0927035-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-07-07 | — | — | EP | disclosed |
| US-5872138-A | INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION IN A MAMMAL | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| WO-1998010763-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-03-19 | — | — | WO | disclosed |