Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.59 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.59 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312726 | 1.00 | ITGB1 (0.59) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7326273 | 0.91 | ITGA4 (0.60) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7326267 | 0.91 | ITGA4 (0.60) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7316222 | 0.91 | ITGA4 (0.59) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7316216 | 0.91 | ITGA4 (0.59) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL3861626 | 0.86 | ITGB1 (0.63) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL27668499 | 0.86 | ITGB1 (0.63) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7325791 | 0.86 | ITGA4 (0.60) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7325788 | 0.86 | ITGA4 (0.60) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 | |
| SCHEMBL7315484 | 0.86 | ITGA4 (0.57) | ITGB1ITGA5ITGA4ALDH1A1ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492421-B1 | BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA | ATHENA NEUROSCIENCES, INC. | 2002-12-10 | — | — | US | claimed |
| EP-1001972-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006431-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | claimed |
| US-6492421-B1 | BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA | ATHENA NEUROSCIENCES, INC. | 2002-12-10 | — | — | US | disclosed |
| EP-1001972-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006431-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | disclosed |