Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 16/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16157213 | 0.80 | PDE3A (0.54) | PDE3APDE3BHRH3KCNH2 | |
| SCHEMBL9602068 | 0.78 | HRH3 (0.57) | PDE3APDE3BHRH3KCNH2MAPT | |
| SCHEMBL10753296 | 0.78 | HRH3 (0.54) | PDE3APDE3BHRH3KCNH2PDE4B | |
| SCHEMBL8305150 | 0.78 | HRH3 (0.54) | PDE3APDE3BHRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL7314082 | 0.77 | HRH3 (0.56) | PDE3APDE3BHRH3KCNH2PDE4B | |
| SCHEMBL10341530 | 0.76 | HRH3 (0.53) | PDE3APDE3BHRH3KCNH2CRBN | |
| SCHEMBL10341521 | 0.75 | HRH3 (0.62) | PDE3APDE3BHRH3KCNH2PDE4B | |
| SCHEMBL9381030 | 0.74 | PDE3B (1.00) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10341574 | 0.74 | PDE3A (0.50) | PDE3APDE3BHRH3KCNH2PDE4B | |
| SCHEMBL10341540 | 0.73 | HRH3 (0.50) | PDE3APDE3BHRH3KCNH2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | claimed |
| US-5246928-A | Cardiovascular disorders | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-21 | — | — | US | disclosed |
| US-5066653-A | Cardiovascular disorders; bronchodilators; phosphodiesterase inhibitors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| US-4906628-A | N-phenylpyridone type III phosphodiesterases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-06 | — | — | US | disclosed |
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | disclosed |