Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318776 | 1.00 | PREP (0.55) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7312769 | 1.00 | PREP (0.55) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9092052 | 0.90 | PREP (0.53) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL809494 | 0.88 | SPHK2 (0.58) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4602602 | 0.88 | SPHK2 (0.58) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5267939 | 0.88 | SPHK2 (0.58) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9202571 | 0.86 | ACE2 (0.56) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL809403 | 0.86 | ACE2 (0.56) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1122261 | 0.86 | PREP (0.55) | PREPACE2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10903579 | 0.86 | CTRB1 (0.57) | PREPACE2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902684-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| WO-1989012633-A1 | BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | E.R. SQUIBB & SONS, INC. (US) | 1989-12-28 | — | — | WO | disclosed |