Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12804717 | 0.93 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL1029349 | 0.93 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL1030470 | 0.93 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL12804931 | 0.92 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL3562146 | 0.92 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL3562143 | 0.92 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL12805601 | 0.90 | TSHR (0.51) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL1073223 | 0.90 | TSHR (0.51) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL3048550 | 0.90 | TSHR (0.51) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL7319478 | 0.89 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |