Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073223 | 1.00 | TSHR (0.51) | TSHRNPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL12805601 | 1.00 | TSHR (0.51) | TSHRNPC1RAB9ASMN1; SMN2GSK3B | |
| Hydrochloric Acid SCHEMBL3048549 | 0.99 | TSHR (0.50) | TSHRNPC1RAB9ASMN1; SMN2GSK3B | |
| Hydrochloric Acid SCHEMBL1073222 | 0.99 | TSHR (0.50) | TSHRNPC1RAB9ASMN1; SMN2GSK3B | |
| Hydrochloric Acid SCHEMBL12805598 | 0.99 | TSHR (0.50) | TSHRNPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL7312903 | 0.90 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL12804717 | 0.88 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL1030470 | 0.88 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL1029349 | 0.88 | GSK3B (0.55) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 | |
| SCHEMBL3562146 | 0.87 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2GSK3BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8203002-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2012-06-19 | — | — | US | disclosed |
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2010-09-02 | — | — | US | disclosed |
| US-7741490-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2010-06-22 | — | — | US | disclosed |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2007-08-16 | — | — | US | disclosed |
| EP-1730129-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | Dipharma S.p.A. (IT) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092871-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | CYP11B2, CYP11B1, CYP4A11 | TSHR 2225/4885NPC1 1798/4885RAB9A 3119/4885 |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | CYP11B2, CYP11B1, CYP4A11 | TSHR 2225/4885NPC1 1798/4885RAB9A 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.