Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425117 | 0.88 | TSHR (0.46) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL9425753 | 0.86 | TSHR (0.44) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL9425543 | 0.83 | TSHR (0.42) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL503651 | 0.82 | SMN1; SMN2 (0.70) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL3216951 | 0.81 | MAPT (0.50) | TSHRSMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL17229449 | 0.81 | SMN1; SMN2 (0.41) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL12636212 | 0.80 | TSHR (0.47) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL8827471 | 0.80 | TSHR (0.47) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL4920850 | 0.80 | TSHR (0.47) | TSHRSMN1; SMN2MAPTL3MBTL1POLB | |
| SCHEMBL3026303 | 0.80 | TSHR (0.47) | TSHRSMN1; SMN2MAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |