Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317140 | 0.80 | HDAC6 (0.51) | HDAC6HDAC1CA1CA2HDAC8 | |
| SCHEMBL7319461 | 0.76 | CA1 (0.38) | HDAC6HDAC1CA1CA2HDAC8 | |
| SCHEMBL7314618 | 0.74 | HDAC6 (0.47) | HDAC6HDAC1CA1CA2HDAC8 | |
| SCHEMBL7325475 | 0.74 | HDAC6 (0.52) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL7311746 | 0.74 | HDAC8 (0.53) | HDAC6HDAC1CA1CA2HDAC8 | |
| SCHEMBL7322131 | 0.73 | HDAC1 (0.45) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7322586 | 0.73 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7317278 | 0.72 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7315757 | 0.72 | HDAC6 (0.53) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7314103 | 0.71 | HDAC6 (0.54) | HDAC6HDAC1HDAC8HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901465-B1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO SPA (IT) | 2000-09-27 | — | — | EP | disclosed |
| US-6034096-A | Compounds with anti-inflammatory and immunosuppressive activities | ITALFARMACO S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |