Sugi Predict

Sugi Predict / Compounds / SCHEMBL7319461

SCHEMBL7319461

SCHEMBL7319461

CON(C(=O)c1ccc(C(=O)NO)cc1)c1cccc2occc12

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ HDAC6 Q9UBN7 14/20 0.38
▸ HDAC8 Q9BY41 5/20 0.38
▸ HDAC2 Q92769 1/20 0.38
▸ HDAC1 Q13547 13/20 0.37
▸ HDAC3 O15379 1/20 0.35
▸ HDAC7 Q8WUI4 1/20 0.35
▸ HDAC10 Q969S8 1/20 0.35
▸ CYP1A1 P04798 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP1B1 Q16678 1/20 0.35
▸ MTNR1A P48039 1/20 0.34
▸ MTNR1B P49286 1/20 0.34
▸ ROCK2 O75116 1/20 0.34
▸ ROCK1 Q13464 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7317140 0.80 HDAC6 (0.51) CA1CA2HDAC6HDAC8HDAC2
SCHEMBL7313703 0.76 HDAC6 (0.39) CA1CA2HDAC6HDAC8HDAC2
SCHEMBL7314618 0.74 HDAC6 (0.47) CA1CA2HDAC6HDAC8HDAC2
SCHEMBL7325475 0.74 HDAC6 (0.52) HDAC6HDAC8HDAC1
SCHEMBL7322337 0.74 TAS1R3 (0.43) CA1CA2HDAC6HDAC8HDAC2
SCHEMBL7322586 0.73 HDAC6 (0.48) HDAC6HDAC8HDAC2HDAC1HDAC3
SCHEMBL7317278 0.72 HDAC6 (0.49) HDAC6HDAC8HDAC2HDAC1HDAC3
SCHEMBL7322131 0.71 HDAC1 (0.45) HDAC6HDAC8HDAC2HDAC1HDAC3
SCHEMBL7310403 0.71 HDAC6 (0.45) HDAC6HDAC8HDAC2HDAC1HDAC3
SCHEMBL7321553 0.70 HDAC6 (0.47) HDAC6HDAC8HDAC2HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230094176-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2023-03-30 — — US disclosed
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
EP-0901465-B1 COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES ITALFARMACO SPA (IT) 2000-09-27 — — EP disclosed
US-6034096-A Compounds with anti-inflammatory and immunosuppressive activities ITALFARMACO S.P.A. (IT) 2000-03-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 CA1 490/4885CA2 675/4885HDAC6 10/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 CA1 490/4885CA2 675/4885HDAC6 10/4885
US-20230094176-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC2, HDAC1 CA1 724/4885CA2 887/4885HDAC6 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.