Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.48 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303020 | 0.89 | ELANE (0.47) | ELANECTRC | |
| SCHEMBL7301006 | 0.86 | ELANE (0.38) | ELANECTRC | |
| SCHEMBL7303022 | 0.85 | ELANE (0.42) | ELANECTRC | |
| SCHEMBL7307045 | 0.84 | ELANE (0.52) | ELANECTRC | |
| SCHEMBL7303844 | 0.84 | ELANE (0.42) | ELANEKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7280555 | 0.79 | ELANE (0.65) | ELANECTRC | |
| SCHEMBL8651546 | 0.69 | ALDH1A1 (0.38) | ELANEKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL7276466 | 0.69 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL9584298 | 0.69 | ELANE (0.57) | ELANECTRC | |
| SCHEMBL9585455 | 0.68 | ELANE (0.59) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |