Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 12/20 | 0.68 |
| ▸ | CA9 | Q16790 | 12/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242464 | 0.89 | CA12 (0.68) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL29853641 | 0.84 | CA12 (0.48) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL26768273 | 0.84 | CA12 (0.48) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL7280334 | 0.83 | CA12 (0.65) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL7281068 | 0.83 | CA12 (0.68) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL1172438 | 0.82 | CA12 (1.00) | CA12CA9CA1HDAC1HDAC2 | |
| SCHEMBL30527996 | 0.82 | CA12 (1.00) | CA12CA9CA1HDAC1HDAC2 | |
| SCHEMBL7281529 | 0.80 | CA12 (0.72) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL7299633 | 0.79 | RAB9A (1.00) | CA12CA9RAB9ACA1HDAC1 | |
| SCHEMBL31658258 | 0.79 | CA12 (0.45) | CA12CA9RAB9ACA1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874432-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-02-23 | — | — | US | disclosed |
| US-5650422-A | TREATMENT OF EMPHYSEMA, ARTHRITIS OR PANCREATITIS | SANOFI (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5236917-A | Respiratory system disorders, antiarthritic agents | STERLING WINTHROP INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |