Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 9/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820600 | 0.86 | AVPR2 (0.53) | AVPR2LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5236886 | 0.81 | AVPR2 (0.64) | AVPR2PDK1PDK2PDK3PDK4 | |
| SCHEMBL9059943 | 0.79 | AVPR2 (0.75) | AVPR2 | |
| SCHEMBL5236665 | 0.78 | AVPR2 (0.58) | AVPR2 | |
| SCHEMBL5235714 | 0.74 | AVPR2 (0.50) | AVPR2GPBAR1 | |
| SCHEMBL5235967 | 0.74 | AVPR2 (0.56) | AVPR2LMNAPOLB | |
| SCHEMBL5238090 | 0.73 | AVPR2 (0.57) | AVPR2LMNASMN1; SMN2RAB9A | |
| SCHEMBL7314107 | 0.73 | HPGD (0.44) | AVPR2LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9059936 | 0.73 | AVPR2 (0.46) | AVPR2SMN1; SMN2 | |
| SCHEMBL8818791 | 0.72 | AVPR2 (0.51) | AVPR2LMNASMN1; SMN2NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |