Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321335 | 0.88 | KDM4E (0.85) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL7315118 | 0.85 | SMN1; SMN2 (0.69) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL7350479 | 0.81 | PDE3B (0.57) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL7315122 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL7315789 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL31117024 | 0.80 | ALDH1A1 (0.61) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL10741604 | 0.80 | PDE3B (0.77) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL16157001 | 0.80 | PDE3B (0.77) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL7314234 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL11293197 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EALDH1A1MAPTPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |
| EP-0008391-A1 | Benzimidazoles, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1980-03-05 | — | — | EP | disclosed |