⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921135 | 1.00 | — | — | |
| SCHEMBL5576942 | 0.74 | ALDH1A1 (0.44) | — | |
| SCHEMBL8807337 | 0.74 | — | — | |
| SCHEMBL91470 | 0.73 | — | — | |
| SCHEMBL29531700 | 0.73 | — | — | |
| SCHEMBL1334170 | 0.73 | HSP90AA1 (0.53) | — | |
| SCHEMBL24309289 | 0.73 | — | — | |
| SCHEMBL1984295 | 0.73 | — | — | |
| SCHEMBL1835630 | 0.73 | — | — | |
| SCHEMBL30398040 | 0.72 | KDM4E (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025136898-A1 | AGONISTS OF TREM2 ACTIVITY | MERCK SHARP & DOHME LLC (US) | 2025-06-26 | — | — | WO | disclosed |
| CN-103492370-B | Substituted diaminocarboxamides and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2016-10-26 | — | — | CN | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| EP-0104104-A1 | Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-03-28 | — | — | EP | disclosed |