Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 15/20 | 0.53 |
| ▸ | ELANE | P08246 | 3/20 | 0.52 |
| ▸ | CTRC | Q99895 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23969584 | 0.86 | CMA1 (0.59) | CMA1ELANECTRC | |
| SCHEMBL24441416 | 0.85 | CMA1 (0.54) | CMA1ELANECTRCCTSLCTSB | |
| SCHEMBL24224266 | 0.85 | ELANE (0.56) | CMA1ELANECTRC | |
| SCHEMBL29356746 | 0.85 | ELANE (0.56) | CMA1ELANECTRC | |
| SCHEMBL7316692 | 0.84 | DPP4 (0.55) | CMA1ELANE | |
| SCHEMBL2162326 | 0.83 | CMA1 (0.61) | CMA1ELANECTSLCTSBCTSK | |
| SCHEMBL17378396 | 0.83 | CMA1 (0.61) | CMA1ELANECTSLCTSBCTSK | |
| SCHEMBL4445986 | 0.83 | CMA1 (0.61) | CMA1ELANECTSLCTSBCTSK | |
| SCHEMBL8168155 | 0.83 | CMA1 (0.61) | CMA1ELANECTSLCTSBCTSK | |
| SCHEMBL13258959 | 0.83 | CMA1 (0.51) | CMA1ELANECTRCCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |