Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 13/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311738 | 0.91 | DPP4 (0.47) | DPP4DPP8DPP9ELANECMA1 | |
| SCHEMBL10063675 | 0.85 | XIAP (0.41) | DPP4DPP8DPP9ELANEXIAP | |
| SCHEMBL7314620 | 0.84 | CMA1 (0.53) | ELANECMA1 | |
| SCHEMBL7318715 | 0.83 | ELANE (0.41) | DPP4DPP8DPP9ELANECMA1 | |
| SCHEMBL13339310 | 0.82 | DPP4 (0.49) | DPP4DPP8DPP9ELANEXIAP | |
| SCHEMBL29973334 | 0.80 | DPP4 (0.64) | DPP4DPP8DPP9ACE2 | |
| SCHEMBL17378387 | 0.80 | ELANE (0.66) | DPP4DPP8DPP9ELANECMA1 | |
| SCHEMBL7315779 | 0.79 | ELANE (0.44) | ELANE | |
| SCHEMBL7315775 | 0.79 | ELANE (0.44) | ELANE | |
| SCHEMBL13036084 | 0.78 | ELANE (0.55) | ELANECMA1PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |