Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OGT | O15294 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322154 | 0.89 | KCNH2 (0.51) | CRBNKCNH2GRIN2BNR3C1PGR | |
| Hydrochloric Acid SCHEMBL7318449 | 0.89 | CRBN (0.51) | CRBNKCNH2GRIN2BNR3C1PGR | |
| Hydrochloric Acid SCHEMBL7316762 | 0.88 | KCNH2 (0.51) | CRBNKCNH2GRIN2BNR3C1PGR | |
| Hydrochloric Acid SCHEMBL7326137 | 0.88 | HTR2A (0.50) | CRBNKCNH2GRIN2BNR3C1PGR | |
| Hydrochloric Acid SCHEMBL7287421 | 0.88 | CRBN (0.52) | CRBNKCNH2GRIN2BNR3C1PGR | |
| SCHEMBL11045144 | 0.85 | KCNH2 (0.55) | CRBNKCNH2GRIN2BNR3C1PGR | |
| SCHEMBL11071810 | 0.84 | NR3C1 (0.56) | CRBNKCNH2GRIN2BNR3C1PGR | |
| SCHEMBL7294289 | 0.83 | CRBN (0.51) | CRBNKCNH2GRIN2BNR3C1PGR | |
| Hydrochloric Acid SCHEMBL11040293 | 0.83 | NR3C1 (0.55) | CRBNKCNH2GRIN2BNR3C1PGR | |
| SCHEMBL11040553 | 0.83 | MEN1 (0.62) | CRBNKCNH2GRIN2BNR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |