Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HMGCR | P04035 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710828 | 0.94 | PTPN7 (0.57) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL22029362 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL4060730 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL4063611 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL9551566 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL31682050 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL31682065 | 0.92 | PTPN7 (0.60) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL6272882 | 0.86 | EPHX2 (0.38) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL16968711 | 0.83 | PTPN7 (0.35) | PTPN7RECQLTDP1MAPTALDH1A1 | |
| SCHEMBL4969330 | 0.78 | PTPN7 (0.64) | PTPN7RECQLTDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964851-A1 | C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION | Abbott Laboratories (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5985911-A | COMBATTING DISEASE STATES INVOLVING TISSUE DEGENERATIVE PROCESSES I.E, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR | ABBOTT LABORATORIES (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998030541-A1 | C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |
| US-4602006-A | Ynenolactone protease inhibitors | SYNTEX (U.S.A.) INC. (US) | 1986-07-22 | — | — | US | disclosed |