SCHEMBL7315600

SCHEMBL7315600

CCN(CC)Cc1ccc2cc(CO)ccc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.50
HDAC6 Q9UBN7 3/20 0.44
HDAC1 Q13547 3/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
BCHE P06276 3/20 0.42
S1PR1 P21453 2/20 0.40
CA12 O43570 1/20 0.40
CA2 P00918 1/20 0.40
CA3 P07451 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22764855 0.82 S1PR1 (0.55) HRH3BCHES1PR1
SCHEMBL20022001 0.82 CYP1A2 (0.61) HRH3HDAC1HDAC8HDAC3HDAC2
Hydrochloric Acid SCHEMBL11280275 0.81 HRH3 (0.47) HRH3HDAC6HDAC1HDAC8HDAC3
SCHEMBL5593365 0.81 HRH3 (0.67) HRH3HDAC6HDAC8
SCHEMBL14562409 0.81 CYP2A6 (0.50) HRH3HDAC6HDAC1HDAC8HDAC3
SCHEMBL7315530 0.81 HRH3 (0.50) HRH3HDAC6HDAC1HDAC8HDAC3
Hydrochloric Acid SCHEMBL27898665 0.79 HRH3 (0.48) HRH3HDAC6HDAC1HDAC8HDAC3
SCHEMBL14562408 0.79 HRH3 (0.48) HRH3HDAC6HDAC1HDAC8HDAC3
SCHEMBL29749150 0.78 CA2 (0.54) CA12CA2CA3CA4CA6
SCHEMBL1206769 0.78 CA2 (0.54) CA12CA2CA3CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066835-A2 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed
WO-2013066835-A2 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed
CN-1105100-C Compounds with anti-inflammatory and immunosuppressive activity ITALFARMACO SPA (IT) 2003-04-09 CN disclosed
EP-0901465-B1 COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES ITALFARMACO SPA (IT) 2000-09-27 EP disclosed
US-6034096-A Compounds with anti-inflammatory and immunosuppressive activities ITALFARMACO S.P.A. (IT) 2000-03-07 US disclosed
CN-1221403-A Compounds with anti-inflammatory and immunosuppressive activity ITALFARMACO SPA (IT) 1999-06-30 CN disclosed
EP-0901465-A1 COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES ITALFARMACO S.p.A. (IT) 1999-03-17 EP disclosed
WO-1997043251-A1 COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES ITALFARMACO S.P.A. (IT) 1997-11-20 WO disclosed