Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.56 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036462 | 0.93 | NPFFR1 (0.52) | NPFFR1NPFFR2DPP4OPRL1POLB | |
| SCHEMBL3408119 | 0.92 | NPFFR1 (0.52) | NPFFR1NPFFR2DPP4POLBCYP2D6 | |
| SCHEMBL5698817 | 0.88 | POLB (0.54) | DPP4OPRL1POLBCYP2D6ALDH1A1 | |
| SCHEMBL23647587 | 0.85 | NPFFR1 (0.52) | NPFFR1NPFFR2DPP4CYP2D6SIGMAR1 | |
| SCHEMBL1997960 | 0.85 | NPFFR1 (0.58) | NPFFR1NPFFR2DPP4OPRL1CYP2D6 | |
| SCHEMBL8606869 | 0.84 | NPFFR1 (0.57) | NPFFR1NPFFR2OPRL1CYP2D6SIGMAR1 | |
| SCHEMBL7306529 | 0.84 | DPP4 (0.53) | NPFFR1NPFFR2DPP4OPRL1POLB | |
| SCHEMBL16420447 | 0.84 | CNR1 (0.47) | DPP4POLBCNR1CNR2SIGMAR1 | |
| SCHEMBL6703813 | 0.83 | NPFFR1 (0.61) | NPFFR1NPFFR2OPRL1CYP2D6SIGMAR1 | |
| SCHEMBL23268296 | 0.83 | NPFFR1 (0.56) | NPFFR1NPFFR2OPRL1CYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294537-B1 | NEUROKININS USED FOR TREATMENT OF DISEASES | SANOFI-SYNTHELABO (FR) | 2001-09-25 | — | — | US | disclosed |
| EP-0673928-B1 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists | SANOFI SYNTHELABO (FR) | 2001-08-29 | — | — | EP | disclosed |
| US-6124316-A | ACTIVE DRUG TREATING PSYCHIATRIC DISEASES, DISEASES OF PSYCHOSOMATIC ORIGIN, OF HYPERTENSION AND, NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 2000-09-26 | — | — | US | disclosed |
| CN-1056605-C | Compounds as selective antagonists of human tachykinin III receptor and uses thereof | SANOFI CORP (FR) | 2000-09-20 | — | — | CN | disclosed |
| US-5942523-A | NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES | SANOFI (FR) | 1999-08-24 | — | — | US | disclosed |
| US-5741910-A | PIPERIDINE DERIVATIVE INTERMEDIATES | SANOFI (FR) | 1998-04-21 | — | — | US | disclosed |
| CN-1128756-A | Compounds as selective antagonists of the human tachykinin III receptor and uses thereof | SANOFI CORP (FR) | 1996-08-14 | — | — | CN | disclosed |
| EP-0673928-A1 | Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists | SANOFI (FR) | 1995-09-27 | — | — | EP | disclosed |