Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554955 | 0.89 | AKT1 (0.47) | CNR1CNR2POLBALDH1A1AKT1 | |
| SCHEMBL16418423 | 0.88 | GRIN2D (0.50) | CNR1CNR2POLBOPRM1KCNH2 | |
| SCHEMBL28480157 | 0.87 | CNR1 (0.46) | CNR1CNR2POLBALDH1A1AKT1 | |
| SCHEMBL89721 | 0.86 | SSTR4 (0.50) | CNR1CNR2POLBALDH1A1AKT1 | |
| SCHEMBL17040898 | 0.86 | SSTR4 (0.47) | CNR1CNR2POLBALDH1A1AKT1 | |
| SCHEMBL7312456 | 0.85 | CNR1 (0.45) | CNR1CNR2POLBOPRM1KCNH2 | |
| SCHEMBL7315847 | 0.84 | NPFFR1 (0.56) | CNR1CNR2DPP4POLBALDH1A1 | |
| SCHEMBL3892253 | 0.83 | OPRM1 (0.45) | CNR1CNR2POLBOPRM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27552695 | 0.82 | OPRM1 (0.44) | CNR1CNR2POLBOPRM1ALDH1A1 | |
| SCHEMBL1412064 | 0.82 | CNR1 (0.44) | CNR1CNR2POLBKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814828-B9 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | RES TRIANGLE INST (US) | 2020-10-07 | — | — | EP | disclosed |
| US-9458160-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2016-10-04 | — | — | US | disclosed |
| US-20160046630-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | RES TRIANGLE INST (US) | 2016-02-18 | — | — | US | disclosed |
| US-9187480-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150031689-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031689-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | CNR1, CNR2, P2RY1 | CNR1 1/4885CNR2 2/4885DPP4 126/4885 |
| US-20160046630-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | CNR1, CNR2, P2RY1 | CNR1 1/4885CNR2 2/4885DPP4 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.