Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427265 | 0.88 | KDM4E (0.59) | ABCB1MEN1KMT2AABCG2TP53 | |
| SCHEMBL8427187 | 0.85 | KDM4E (0.74) | ABCB1MEN1KMT2AABCG2TP53 | |
| Recoflavone SCHEMBL29406117 | 0.83 | ABCB1 (0.59) | ABCB1MEN1KMT2AABCG2TP53 | |
| Recoflavone SCHEMBL2483541 | 0.83 | ABCB1 (0.59) | ABCB1MEN1KMT2AABCG2TP53 | |
| SCHEMBL2481857 | 0.83 | MEN1 (0.59) | ABCB1MEN1KMT2AABCG2TP53 | |
| SCHEMBL8305990 | 0.82 | MAOB (0.66) | ABCB1MEN1KMT2AABCG2TP53 | |
| SCHEMBL14178905 | 0.82 | ABCB1 (0.58) | ABCB1MEN1KMT2AABCG2TP53 | |
| Recoflavone SCHEMBL2483546 | 0.82 | ABCB1 (0.58) | ABCB1MEN1KMT2AABCG2TP53 | |
| Recoflavone SCHEMBL7603767 | 0.82 | ABCB1 (0.58) | ABCB1MEN1KMT2AABCG2TP53 | |
| Recoflavone SCHEMBL7603759 | 0.81 | ABCB1 (0.57) | ABCB1MEN1KMT2AABCG2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014131995-A1 | METHOD FOR THE ENZYMATIC SYNTHESIS OF DIOSMETIN DERIVATIVES | LES LABORATOIRES SERVIER (FR) | 2014-09-04 | — | — | WO | disclosed |
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | disclosed |
| US-8404742-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them | Les Laboratories Server (FR) | 2013-03-26 | — | — | US | disclosed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | disclosed |
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2012-08-16 | — | — | US | disclosed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | disclosed |
| US-8138223-B2 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2012-03-20 | — | — | US | disclosed |
| WO-2009133269-A1 | NOVEL DIOMESTINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133269-A1 | NOVEL DIOMESTINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-11-05 | — | — | WO | disclosed |
| EP-2107055-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-10-07 | — | — | EP | disclosed |
| EP-2107055-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-10-07 | — | — | EP | disclosed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | LES LABORATOIRES SERVIER (FR) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208777-A1 | DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EDF1, EDNRA, EDNRB | ABCB1 1041/4885MEN1 143/4885KMT2A 3640/4885 |
| US-20090247621-A1 | Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them | EDF1, EDNRA, EDNRB | ABCB1 1026/4885MEN1 197/4885KMT2A 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.